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Posted -  8/21/2018  :  12:25:53 PM
The precise mechanisms by which cheap neurontin capsules online produces its analgesic and antiepileptic actions are unknown. cheap neurontin capsules online is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. In vitro studies have shown that cheap neurontin capsules online binds with high-affinity to the ?2? subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of cheap neurontin capsules online is unknown. neurontin was administered orally to mice and rats in 2-year carcinogenicity studies. No evidence of drug-related carcinogenicity was observed in mice treated at doses up to 2000 mg/kg/day. At 2000 mg/kg, the plasma neurontin exposure (AUC) in mice is approximately 2 times that in humans at the MRHD of 3600 mg/day. In rats, increases in the incidence of pancreatic acinar cell adenoma and carcinoma were found in male rats receiving the highest dose (2000 mg/kg), but not at doses of 250 or 1000 mg/kg/day. At 1000 mg/kg, the plasma neurontin exposure (AUC) in rats is approximately 5 times that in humans at the MRHD. There are no adequate and well-controlled studies in pregnant women. In nonclinical studies in mice, rats, and rabbits, neurontin was developmentally toxic when administered to pregnant animals at doses similar to or lower than those used clinically. neurontin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking neurontin without first talking with your healthcare provider. Taking neurontin with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse. Do not drive, operate heavy machinery, or do other dangerous activities until you know how neurontin affects you. neurontin can slow your thinking and motor skills. 

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